Our Blog
Your introductory knowledge hub for soft capsules.
Crosslinking in Softgel Capsules: An Intro
Drug product stability testing is not exactly glamorous work. It is slow, methodical, and expensive, and when it fails, it tends to fail late, after months of effort. For softgel capsules specifically, the stakes are higher than most anticipate.
Stability Testing for Softgel Capsules
Drug product stability testing is not exactly glamorous work. It is slow, methodical, and expensive, and when it fails, it tends to fail late, after months of effort. For softgel capsules specifically, the stakes are higher than most anticipate.
Webinar Recap: CDMOs for Softgel Capsules
Last week, we hosted a webinar on CDMOs for softgel capsules that brought together an engaged audience of pharmaceutical industry professionals from around the world. The strong turnout reflects just how critical—and how complex—the topic of outsourcing softgel manufacturing has become for pharma and biotech companies navigating today's market.
Understanding Late Leakage in Softgel Capsules: Causes and Prevention
Late-stage leakage is one of the most frustrating phenomena in softgel development. In any given project, softgel capsules pass initial quality control and survive months of stability testing, but can then begin leaking.
What are plasticizers, and how do they affect softgels?
Plasticizers are the unsung heroes of softgel formulations. While gelatin provides the structural backbone, plasticizers are what transform a rigid protein matrix into the flexible, robust capsules.
Webinar Recap: Leakers in Softgel Capsules
Last week, we hosted a technical webinar on leakers in softgel capsules that attracted hundreds of attendees from pharmaceutical companies, CDMOs, and supplement manufacturers worldwide. The strong turnout confirms that leakage remains one of the most critical quality challenges in softgel manufacturing.
Meet the Expert: Pearl Pereira- Nambiar
To continue our Meet the Expert series, we're delighted to feature Pearl Pereira Nambiar, a seasoned pharmaceutical development expert with over two decades of specialized experience in analytical development strategy and regulatory science.
Webinar Recap: Crosslinking in Softgel Capsules
A few weeks ago, we hosted a webinar on crosslinking in soft gel capsules that drew an impressive audience of over 350 registrants from across the pharmaceutical industry. This remarkable turnout demonstrates that crosslinking remains a critical challenge worthy of attention for soft gel manufacturers and formulation scientists.
Meet the Expert: Vitor Antraco
To continue our Meet the Expert series, we're delighted to feature Vitor Antraco. He is a passionate softgel formulation specialist based in Sao Paulo, Brazil, with extensive experience in pharmaceutical and nutritional supplement applications. Having developed more than 15 softgel products and served as an R&D head, Vitor brings valuable insights into the art and science of softgel technology.
Softgel capsule or liquid-filled hard capsule: Which one should you choose?
Choosing the right dosage form is a critical decision in pharmaceutical development. For liquid single-unit preparations, selecting between softgel and liquid-filled hard capsulesrequires careful evaluation. Both options present distinct manufacturing challenges, cost implications, and performance characteristics.
What determines the shelf life of softgel capsules?
Understanding the shelf life of softgel capsules can be particularly challenging. This article breaks down the science behind expiration dates in softgel capsules.
Softgel Capsules Explained: The Ultimate FAQ Guide (Part II)
Discover the most frequently asked questions about the intricacies of softgel capsules from the technical point of view.
Softgel Capsules Explained: The Ultimate FAQ Guide (Part I)
Discover the most frequently asked questions from the consumer point of view about softgel capsules.
3 key factors for successful shell development
This article highlights 3 key aspects of shell formulation development, from raw material selection to addressing common compatibility issues. A well-designed capsule shell is the key to unlocking the full potential of the encapsulated fill, ensuring that the product remains stable throughout its shelf life.
Meet the Expert: Dr. Samir Haddouchi
To kick off our Meet the Expert series, we’re excited to feature Dr. Samir Haddouchi, Managing Director at SOTAX Pharma Services (SPS), and a leading expert in dissolution testing of softgel capsules.
Transfer of soft capsule products between 2 CMOs: best practices
The transfer of softgel capsule manufacturing between contract manufacturing organizations (CMOs) is a complex process that is often underestimated.
Choosing the right CDMO partnership model for softgel development
In today's pharmaceutical industry, partnerships between pharmaceutical companies and Contract Development and Manufacturing Organizations (CDMOs) are crucial for the successful development and commercialization of drugs. Choosing a CDMO itself can be a game-changer.
Softgels vs. tablets vs. capsules: what's the difference?
When developing new drug products, pharmaceutical companies often choose between three main dosage forms: tablets, hard capsules, and softgel capsules. This decision is a critical juncture in the development process, as each option has its own unique characteristics and benefits.
SMEDDS in softgel capsules: opportunities and pitfalls
SMEDDS is an acronym for Self Micro-Emulsifying Drug Delivery System. SMEDDS formulations are a clear solution of a drug substance which spontaneously form an oil-in water (O/W) microemulsion upon dispersion in water. In the emulsion the drug substance is incorporated within droplets with a size of 50-200 µm. A SMEDDS formulation typically contains a lipid solvent, one or more surfactants and optionally a co-solvent.