Our Blog

Your introductory knowledge hub for soft capsules.

Crosslinking in Softgel Capsules: An Intro
Yanitsa Miteva Yanitsa Miteva

Crosslinking in Softgel Capsules: An Intro

Drug product stability testing is not exactly glamorous work. It is slow, methodical, and expensive, and when it fails, it tends to fail late, after months of effort. For softgel capsules specifically, the stakes are higher than most anticipate. 

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Stability Testing for Softgel Capsules
Yanitsa Miteva Yanitsa Miteva

Stability Testing for Softgel Capsules

Drug product stability testing is not exactly glamorous work. It is slow, methodical, and expensive, and when it fails, it tends to fail late, after months of effort. For softgel capsules specifically, the stakes are higher than most anticipate. 

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Webinar Recap: CDMOs for Softgel Capsules
Andres Zambrano-Bravo Andres Zambrano-Bravo

Webinar Recap: CDMOs for Softgel Capsules

Last week, we hosted a webinar on CDMOs for softgel capsules that brought together an engaged audience of pharmaceutical industry professionals from around the world. The strong turnout reflects just how critical—and how complex—the topic of outsourcing softgel manufacturing has become for pharma and biotech companies navigating today's market.

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Webinar Recap: Leakers in Softgel Capsules
Andres Zambrano-Bravo Andres Zambrano-Bravo

Webinar Recap: Leakers in Softgel Capsules

Last week, we hosted a technical webinar on leakers in softgel capsules that attracted hundreds of attendees from pharmaceutical companies, CDMOs, and supplement manufacturers worldwide. The strong turnout confirms that leakage remains one of the most critical quality challenges in softgel manufacturing.

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Meet the Expert: Pearl Pereira- Nambiar
Andres Zambrano-Bravo Andres Zambrano-Bravo

Meet the Expert: Pearl Pereira- Nambiar

To continue our Meet the Expert series, we're delighted to feature Pearl Pereira Nambiar, a seasoned pharmaceutical development expert with over two decades of specialized experience in analytical development strategy and regulatory science.

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Webinar Recap: Crosslinking in Softgel Capsules
Andres Zambrano-Bravo Andres Zambrano-Bravo

Webinar Recap: Crosslinking in Softgel Capsules

A few weeks ago, we hosted a webinar on crosslinking in soft gel capsules that drew an impressive audience of over 350 registrants from across the pharmaceutical industry. This remarkable turnout demonstrates that crosslinking remains a critical challenge worthy of attention for soft gel manufacturers and formulation scientists.

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Meet the Expert: Vitor Antraco
Andres Zambrano-Bravo Andres Zambrano-Bravo

Meet the Expert: Vitor Antraco

To continue our Meet the Expert series, we're delighted to feature Vitor Antraco. He is a passionate softgel formulation specialist based in Sao Paulo, Brazil, with extensive experience in pharmaceutical and nutritional supplement applications. Having developed more than 15 softgel products and served as an R&D head, Vitor brings valuable insights into the art and science of softgel technology.

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Softgel capsule or liquid-filled hard capsule: Which one should you choose?
Andres Zambrano-Bravo Andres Zambrano-Bravo

Softgel capsule or liquid-filled hard capsule: Which one should you choose?

Choosing the right dosage form is a critical decision in pharmaceutical development. For liquid single-unit preparations, selecting between softgel and liquid-filled hard capsulesrequires careful evaluation. Both options present distinct manufacturing challenges, cost implications, and performance characteristics. 

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3 key factors for successful shell development
Andres Zambrano-Bravo Andres Zambrano-Bravo

3 key factors for successful shell development

This article highlights 3 key aspects of shell formulation development, from raw material selection to addressing common compatibility issues. A well-designed capsule shell is the key to unlocking the full potential of the encapsulated fill, ensuring that the product remains stable throughout its shelf life.

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Meet the Expert: Dr. Samir Haddouchi
Andres Zambrano-Bravo Andres Zambrano-Bravo

Meet the Expert: Dr. Samir Haddouchi

To kick off our Meet the Expert series, we’re excited to feature Dr. Samir Haddouchi, Managing Director at SOTAX Pharma Services (SPS), and a leading expert in dissolution testing of softgel capsules.

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Choosing the right CDMO partnership model for softgel  development
Andres Zambrano-Bravo Andres Zambrano-Bravo

Choosing the right CDMO partnership model for softgel development

In today's pharmaceutical industry, partnerships between pharmaceutical companies and Contract Development and Manufacturing Organizations (CDMOs) are crucial for the successful development and commercialization of drugs. Choosing a CDMO itself can be a game-changer.

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Softgels vs. tablets vs. capsules: what's the difference?
Andres Zambrano-Bravo Andres Zambrano-Bravo

Softgels vs. tablets vs. capsules: what's the difference?

When developing new drug products, pharmaceutical companies often choose between three main dosage forms: tablets, hard capsules, and softgel capsules. This decision is a critical juncture in the development process, as each option has its own unique characteristics and benefits.

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SMEDDS in softgel capsules: opportunities and pitfalls
Yanitsa Miteva Yanitsa Miteva

SMEDDS in softgel capsules: opportunities and pitfalls

SMEDDS is an acronym for Self Micro-Emulsifying Drug Delivery System. SMEDDS formulations are a clear solution of a drug substance which spontaneously form an oil-in water (O/W) microemulsion upon dispersion in water. In the emulsion the drug substance is incorporated within droplets with a size of 50-200 µm. A SMEDDS formulation typically contains a lipid solvent, one or more surfactants and optionally a co-solvent.

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