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The manufacturing process of softgel capsules
Soft capsules are commercially manufactured applying the rotary-die technology, a technique that traces its roots back to the 19th century with the innovations of the pharmacist Robert P. Scherer. It involves a series of operations which are performed in parallel to each other and are typically highly standardised at each manufacturer: gel mass preparation, filll mass preparation, encapsulation, drying, inspection and (bulk) packaging.
What are softgel capsules?
Soft capsules are a solid oral dosage form a liquid or semi-solid capsule fill containing the active ingredient dosed into a hermetically sealed capsule shell.
While soft capsules have been known and patented first in the 1830s, the most common process for their commercial-scale production, the rotary-die encapsulation, was patented by R.P. Scherrer in 1933.